This is a board, not an offer: it says what runs on this route at all. Nothing here is
booked, and no price was checked for a particular day — the ranges are what a ticket usually costs.
No direct flights exist since Ukraine's airspace is closed; flying to Warsaw and taking the overnight sleeper train is the fastest and most comfortable way in, with all-rail, direct bus, or self-driving as slower alternatives.
By air
Fly to Warsaw, then overnight sleeper train · Wizz Air, Ryanair, LOT Polish Airlines, ITA Airways, Ukrzaliznytsia (night train 67/68)
24 h 30 mindaily€50 — €160
Several flights a day Rome–Warsaw (~2h20m); the Warsaw–Kyiv sleeper leaves only once daily in the early evening, so expect a multi-hour layover before boarding it, arriving Kyiv the next morning.
By train
All-rail via Vienna, Kraków and Przemyśl · ÖBB Nightjet (Rome–Vienna), ÖBB/PKP (Vienna–Kraków), Regiojet/PKP (Kraków–Przemyśl), Ukrzaliznytsia "Oberig" (Przemyśl–Kyiv)
37 h 10 mindaily
No flying at all: overnight Nightjet to Vienna, regional connections on to Kraków and Przemyśl, then the overnight Oberig service into Kyiv. Several changes — check connection times before booking.
By bus
Direct long-haul coach · Infobus, Euroticket, FlixBus, Sindbad
40 hdaily€80 — €160
Coach runs via Austria/Slovakia or Poland; long queues at the Ukrainian border are common and can add hours to the trip.
By car
Self-drive via Austria and Poland · own vehicle / private driver
30 hdaily
About 2,350 km, crossing near Medyka/Shehyni or Korczowa/Krakovets; most European rental contracts forbid taking the car into Ukraine, so this suits your own vehicle or a private driver who handles the border crossing.
Could not find out: Couldn't confirm a reliable price range for the all-rail Vienna/Kraków itinerary or fuel/toll costs for driving; didn't check Rzeszów or Chișinău as alternative flight gateways, which may work better for some travelers.