This is a board, not an offer: it says what runs on this route at all. Nothing here is
booked, and no price was checked for a particular day — the ranges are what a ticket usually costs.
For this ~350 km corridor the direct EuroCity train (about 4h20) is the sensible default; flying needs a connection and ends up slower door-to-door, while the bus is only slightly cheaper but slower.
By air
Connecting flight (no direct route) · Lufthansa, KLM, ITA Airways
6 hdaily€70 — €250
No nonstop flights exist between Berlin and Prague; every option connects via Munich, Vienna or Frankfurt, which usually makes it slower than the train once airport time and layover are counted.
By train
Direct EuroCity train · Deutsche Bahn, České dráhy
4 h 20 mindaily€20 — €90
5-6 direct departures a day, journey 4h20-4h40; new ComfortJet trains from 2026. A March-December 2026 track upgrade cancels most Monday departures except the 17:28 and 19:28 from Berlin and the 06:31 from Prague.
By bus
Intercity coach · FlixBus, RegioJet
4 h 30 mindaily€15 — €45
Combined FlixBus and RegioJet departures run roughly every 1-2 hours, journey about 4h20-4h56; cheapest option but exposed to road traffic.
By car
Self-drive (own or rental car)
3 h 45 mindaily
About 350 km via A13/A4 then the D8 into Prague, roughly 3h40-4h without traffic; a Czech highway vignette is required (about EUR 14 for 10 days). Cost depends heavily on fuel vs. rental, so no fixed price is given.
Intercity carpool (BlaBlaCar-style ride-share) · BlaBlaCar
4 h 20 mindaily€20 — €35
Shared rides cover this corridor multiple times a day; schedule and comfort depend on the individual driver, with pickup/drop-off outside the city center.
Could not find out: Fare ranges are typical seasonal figures, not live prices; today's actual ticket cost and connecting-flight prices weren't checked live.